pentobarbital decreases levels of ponatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Steer clear of Except the coadministration outweighs the achievable threat of ponatinib underexposure; keep track of for signs of lessened efficacy.fentanyl transmucosal and pentobarbital both increase sedation